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Le changement climatique va accélérer les transmissions virales entre espèces

Alpitour: ?Io in un villaggio? Mai!?. Parte una campagna da 4 mln di euro

Nourrir des « chats » quantiques pour doper les calculs

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                    [title] => Le changement climatique va accélérer les transmissions virales entre espèces
                    [link] => https://moustachebrothers.com/planet/le-changement-climatique-va-accelerer-les-transmissions-virales-entre-especes/
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                            [creator] => Tim Hall
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                    [pubdate] => Fri, 29 Apr 2022 04:44:41 +0000
                    [category] => PlanetaccélérerChangementclimatiqueentreespècesLestransmissionsvirales
                    [guid] => https://moustachebrothers.com/?p=36642
                    [description] => Des chauves-souris dans l?archipel des îles de la Sonde (Nusa Tenggara), en Indonésie. FRÉDÉRIC SOREAU / PHOTONONSTOP / FRÉDÉRIC SOREAU / PHOTONONSTOP « Les décennies à venir seront non seulement plus chaudes mais plus malades. » C?est avec cette phrase-choc que Gregory Albery, du département de biologie de l?université de Georgetown, à Washington, résume le travail qu?il ... Read more
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« Les décennies à venir seront non seulement plus chaudes mais plus malades. » C?est avec cette phrase-choc que Gregory Albery, du département de biologie de l?université de Georgetown, à Washington, résume le travail qu?il a mené, avec Colin Carlson et d?autres membres de l?ONG américaine EcoHealth Alliance, sur les conséquences du changement climatique sur les risques de transmission virale entre différentes espèces animales. Dans cette étude publiée jeudi 28 avril dans la revue Nature, les auteurs estiment, à l?aide de modèles et de bases de données complexes, qu?au moins 15 000 nouvelles transmissions interespèces devraient intervenir d?ici à 2070. « Nous avons démontré un nouveau mécanisme potentiellement dévastateur pour l?émergence de maladies qui pourraient menacer la santé de la population animale, avec, pour la plupart, des ramifications pour notre santé », souligne Gregory Albery.
Poussées par le changement climatique à se déplacer pour survivre, de nombreuses espèces animales vont parcourir une centaine, ou plus, de kilomètres dans le siècle à venir, emportant avec elles leurs parasites et agents pathogènes. Ces mouvements à large échelle vont provoquer de nombreuses rencontres, jusque-là inédites, entre des espèces qui évoluaient, auparavant, dans des environnements séparés, créant autant de possibilités de transmission de virus et d?autres bactéries potentiellement dangereuses entre animaux. « Le point intéressant de cette étude est qu?elle montre que de nouvelles coexistences d?espèces vont advenir à large échelle spatiale, les barrières de rencontre vont disparaître, souligne Jean-François Guégan, directeur de recherche à l?Institut de recherche pour le développement et à l?Institut national de recherche pour l?agronomie, l?alimentation et l?environnement, qui n?a pas contribué à l?étude. Cette ?tectonique des espèces? va provoquer de plus en plus de transmissions virales ou bactériennes entre espèces, parfois quasiment imprévisibles. »
Des « hotspots » en Afrique, en Asie et en Europe
L?ampleur de ce phénomène dépendra en grande partie de la compatibilité entre ces virus et leurs potentiels nouveaux hôtes, ainsi que des aires de chevauchement des bassins de vie des différentes espèces. Dans tous les cas, les auteurs de l?étude alertent sur le fait que ces échanges viraux ne sont, pour la plupart, pas étudiés et risquent à terme de provoquer des zoonoses, c?est-à-dire la transmission de certains de ces virus à la population humaine.
Lire aussi :  Article réservé à nos abonnés  Le concept « One Health », une approche scientifique multidisciplinaire pour mieux prévenir les pandémies  
Les scientifiques ont ainsi identifié différents « hotspots », des lieux particulièrement propices aux rencontres et transmissions virales interespèces, qui coïncideront largement avec une forte densité de population en 2070, notamment dans le Sahel, les hauts plateaux éthiopiens ainsi que la vallée du Rift, l?Inde, l?est de la Chine, l?Indonésie et les Philippines. Certains territoires européens ont également été identifiés. Des pathogènes récemment apparus comme le virus Usutu, qui a notamment décimé la population de merles noirs en Europe, « montrent que ces populations peuvent encore être vulnérables, malgré une surveillance et un accès aux soins accrus », avertissent les auteurs.
Il vous reste 50.94% de cet article à lire. La suite est réservée aux abonnés.

We  want to  give thanks to the author of this article for this  remarkable  material



Le changement climatique va accélérer les transmissions virales entre espèces


                        )

                    [summary] => Des chauves-souris dans l?archipel des îles de la Sonde (Nusa Tenggara), en Indonésie. FRÉDÉRIC SOREAU / PHOTONONSTOP / FRÉDÉRIC SOREAU / PHOTONONSTOP « Les décennies à venir seront non seulement plus chaudes mais plus malades. » C?est avec cette phrase-choc que Gregory Albery, du département de biologie de l?université de Georgetown, à Washington, résume le travail qu?il ... Read more
                    [atom_content] => 

  
« Les décennies à venir seront non seulement plus chaudes mais plus malades. » C?est avec cette phrase-choc que Gregory Albery, du département de biologie de l?université de Georgetown, à Washington, résume le travail qu?il a mené, avec Colin Carlson et d?autres membres de l?ONG américaine EcoHealth Alliance, sur les conséquences du changement climatique sur les risques de transmission virale entre différentes espèces animales. Dans cette étude publiée jeudi 28 avril dans la revue Nature, les auteurs estiment, à l?aide de modèles et de bases de données complexes, qu?au moins 15 000 nouvelles transmissions interespèces devraient intervenir d?ici à 2070. « Nous avons démontré un nouveau mécanisme potentiellement dévastateur pour l?émergence de maladies qui pourraient menacer la santé de la population animale, avec, pour la plupart, des ramifications pour notre santé », souligne Gregory Albery.
Poussées par le changement climatique à se déplacer pour survivre, de nombreuses espèces animales vont parcourir une centaine, ou plus, de kilomètres dans le siècle à venir, emportant avec elles leurs parasites et agents pathogènes. Ces mouvements à large échelle vont provoquer de nombreuses rencontres, jusque-là inédites, entre des espèces qui évoluaient, auparavant, dans des environnements séparés, créant autant de possibilités de transmission de virus et d?autres bactéries potentiellement dangereuses entre animaux. « Le point intéressant de cette étude est qu?elle montre que de nouvelles coexistences d?espèces vont advenir à large échelle spatiale, les barrières de rencontre vont disparaître, souligne Jean-François Guégan, directeur de recherche à l?Institut de recherche pour le développement et à l?Institut national de recherche pour l?agronomie, l?alimentation et l?environnement, qui n?a pas contribué à l?étude. Cette ?tectonique des espèces? va provoquer de plus en plus de transmissions virales ou bactériennes entre espèces, parfois quasiment imprévisibles. »
Des « hotspots » en Afrique, en Asie et en Europe
L?ampleur de ce phénomène dépendra en grande partie de la compatibilité entre ces virus et leurs potentiels nouveaux hôtes, ainsi que des aires de chevauchement des bassins de vie des différentes espèces. Dans tous les cas, les auteurs de l?étude alertent sur le fait que ces échanges viraux ne sont, pour la plupart, pas étudiés et risquent à terme de provoquer des zoonoses, c?est-à-dire la transmission de certains de ces virus à la population humaine.
Lire aussi :  Article réservé à nos abonnés  Le concept « One Health », une approche scientifique multidisciplinaire pour mieux prévenir les pandémies  
Les scientifiques ont ainsi identifié différents « hotspots », des lieux particulièrement propices aux rencontres et transmissions virales interespèces, qui coïncideront largement avec une forte densité de population en 2070, notamment dans le Sahel, les hauts plateaux éthiopiens ainsi que la vallée du Rift, l?Inde, l?est de la Chine, l?Indonésie et les Philippines. Certains territoires européens ont également été identifiés. Des pathogènes récemment apparus comme le virus Usutu, qui a notamment décimé la population de merles noirs en Europe, « montrent que ces populations peuvent encore être vulnérables, malgré une surveillance et un accès aux soins accrus », avertissent les auteurs.
Il vous reste 50.94% de cet article à lire. La suite est réservée aux abonnés.

We  want to  give thanks to the author of this article for this  remarkable  material



Le changement climatique va accélérer les transmissions virales entre espèces


                    [date_timestamp] => 1651207481
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            [1] => Array
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                    [title] => Alpitour: ?Io in un villaggio? Mai!?. Parte una campagna da 4 mln di euro
                    [link] => https://moustachebrothers.com/lifestyle/alpitour-io-in-un-villaggio-mai-parte-una-campagna-da-4-mln-di-euro/
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                            [creator] => Paula Hooper
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                    [pubdate] => Fri, 29 Apr 2022 04:43:57 +0000
                    [category] => LifestyleAlpitourcampagnaEuroMaimlnparteunavillaggio
                    [guid] => https://moustachebrothers.com/?p=36636
                    [description] => Una campagna promozionale da 4 milioni di euro complessivi. E questo solo per la parte iniziale di una più ampia strategia di comunicazione, che prevede iniziative ad hoc per ciascuno dei tre pillar della compagnia, prolungate e ripetute negli anni. Alpitour torna in comunicazione e lo fa con una creatività dedicata al prodotto villaggio, che ... Read more
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Una campagna promozionale da 4 milioni di euro complessivi. E questo solo per la parte iniziale di una più ampia strategia di comunicazione, che prevede iniziative ad hoc per ciascuno dei tre pillar della compagnia, prolungate e ripetute negli anni. Alpitour torna in comunicazione e lo fa con una creatività dedicata al prodotto villaggio, che mira a ribaltare alcuni pregiudizi diffusi, persino quelli creati dalla stessa fortunatissima pubblicità degli anni 1980. Ecco quindi il claim del nuovo spot ?Io in un villaggio? Mai?, che si trasforma in un atteggiamento progressivamente più possibilista man mano che il protagonista dello spot tocca con mano le esperienze disponibili in una vacanza Alpitour. ?Volevamo comunicare il turismo organizzato in maniera ironica ma moderna: spiegare che il soggiorno in un villaggio non è solo una cosa vintage, ma un?esperienza contemporanea, piacevole e con tanti servizi in più?, racconta il general manager tour operating, Pier Ezhaya.
L?idea, sostanzialmente, è quella di raggiungere quella parte di pubblico, spesso i più giovani, che non sono consapevoli di come i villaggi siano stati in grado di  evolvere il proprio prodotto negli anni. ?La nostra proposta è cambiata per rimanere al passo coi tempi, ma a volte non è mutata la percezione delle persone nei confronti dei villaggi ? aggiunge l?head of corporate & tour operating marketing, Tommaso Bertini -. Ecco allora la necessità di comunicare i vantaggi di una vacanza con noi. Tanto più in un momento nel quale la sbornia dell?online si sta progressivamente ridimensionando, mentre sicurezza e tranquillità stanno diventano fattori di scelta sempre più rilevanti tra i consumatori?. Lo spot mira perciò a veicolare un messaggio di apertura: ?L?invito è a mandare in vacanza i luoghi comuni?, sottolinea Mirco Pagano, chief creative officer di Tbwa Italia, l?agenzia incaricata della creatività.
Ma come si diceva, questa è solo la prima parte di una  strategia di promozione molto più vasta, che coinvolgerà presto tutti e tre i pillar della Trevolution con modalità e strategie dedicate. La stessa Trevolution, anzi, è stata propedeutica al ritorno in comunicazione della compagnia. Oggi, osserva infatti Ezhaya, nel turismo è necessario presentarsi al pubblico con pochi marchi ma chiaramente identificabili. ?In tutti i casi parliamo di pianificazioni omnicanale: dalla tv, tradizionale e digital, fino ai  social e in generale a tutto il mondo del web ? rivela Bertini -. La campagna Alpitour sarà in particolare on air e online a maggio e giugno, per poi essere ripetuta a settembre e ottobre. Per quanto riguarda Eden Viaggi, invece, già dalla prossima settimana partiremo con una serie di iniziative volte a rendere il marchio un punto di riferimento per chi è alla ricerca di una vacanza al contempo no-frills e capace di garantire tutta la sicurezza e l?assistenza di un viaggio organizzato. Parleremo a un pubblico naturalmente diverso da quello del pillar mainstream, la campagna avrà quindi un bilanciamento media differente e più spostato verso i canali digital. Per quanto riguarda Turisanda e il cluster Specialties & goal oriented, infine, l?obiettivo sarà quello di avvicinare chi è alla ricerca di un?offerta tailor made non necessariamente dedicata esclusivamente a portafogli importanti. E ciò anche grazie alla presenza delle line Presstour e Made?.
Ora non resta che capire l?efficacia di un investimento tanto importante. Ed ecco allora che Alpitour ha già avviato, in collaborazione con Wavemaker, una rilevazione ad hoc per misurare il grado di notorietà e consideration dei marchi del gruppo. L?analisi verrà poi ripetuta al termine del primo bimestre di campagna Alpitour e alla fine del secondo, proprio per capire come e quanto muterà il percepito dei brand tra i consumatori.
 
 

We  would love to  say thanks to the author of this  write-up for this  amazing  material



Alpitour: “Io in un villaggio? Mai!”. Parte una campagna da 4 mln di euro


                        )

                    [summary] => Una campagna promozionale da 4 milioni di euro complessivi. E questo solo per la parte iniziale di una più ampia strategia di comunicazione, che prevede iniziative ad hoc per ciascuno dei tre pillar della compagnia, prolungate e ripetute negli anni. Alpitour torna in comunicazione e lo fa con una creatività dedicata al prodotto villaggio, che ... Read more
                    [atom_content] => 


Una campagna promozionale da 4 milioni di euro complessivi. E questo solo per la parte iniziale di una più ampia strategia di comunicazione, che prevede iniziative ad hoc per ciascuno dei tre pillar della compagnia, prolungate e ripetute negli anni. Alpitour torna in comunicazione e lo fa con una creatività dedicata al prodotto villaggio, che mira a ribaltare alcuni pregiudizi diffusi, persino quelli creati dalla stessa fortunatissima pubblicità degli anni 1980. Ecco quindi il claim del nuovo spot ?Io in un villaggio? Mai?, che si trasforma in un atteggiamento progressivamente più possibilista man mano che il protagonista dello spot tocca con mano le esperienze disponibili in una vacanza Alpitour. ?Volevamo comunicare il turismo organizzato in maniera ironica ma moderna: spiegare che il soggiorno in un villaggio non è solo una cosa vintage, ma un?esperienza contemporanea, piacevole e con tanti servizi in più?, racconta il general manager tour operating, Pier Ezhaya.
L?idea, sostanzialmente, è quella di raggiungere quella parte di pubblico, spesso i più giovani, che non sono consapevoli di come i villaggi siano stati in grado di  evolvere il proprio prodotto negli anni. ?La nostra proposta è cambiata per rimanere al passo coi tempi, ma a volte non è mutata la percezione delle persone nei confronti dei villaggi ? aggiunge l?head of corporate & tour operating marketing, Tommaso Bertini -. Ecco allora la necessità di comunicare i vantaggi di una vacanza con noi. Tanto più in un momento nel quale la sbornia dell?online si sta progressivamente ridimensionando, mentre sicurezza e tranquillità stanno diventano fattori di scelta sempre più rilevanti tra i consumatori?. Lo spot mira perciò a veicolare un messaggio di apertura: ?L?invito è a mandare in vacanza i luoghi comuni?, sottolinea Mirco Pagano, chief creative officer di Tbwa Italia, l?agenzia incaricata della creatività.
Ma come si diceva, questa è solo la prima parte di una  strategia di promozione molto più vasta, che coinvolgerà presto tutti e tre i pillar della Trevolution con modalità e strategie dedicate. La stessa Trevolution, anzi, è stata propedeutica al ritorno in comunicazione della compagnia. Oggi, osserva infatti Ezhaya, nel turismo è necessario presentarsi al pubblico con pochi marchi ma chiaramente identificabili. ?In tutti i casi parliamo di pianificazioni omnicanale: dalla tv, tradizionale e digital, fino ai  social e in generale a tutto il mondo del web ? rivela Bertini -. La campagna Alpitour sarà in particolare on air e online a maggio e giugno, per poi essere ripetuta a settembre e ottobre. Per quanto riguarda Eden Viaggi, invece, già dalla prossima settimana partiremo con una serie di iniziative volte a rendere il marchio un punto di riferimento per chi è alla ricerca di una vacanza al contempo no-frills e capace di garantire tutta la sicurezza e l?assistenza di un viaggio organizzato. Parleremo a un pubblico naturalmente diverso da quello del pillar mainstream, la campagna avrà quindi un bilanciamento media differente e più spostato verso i canali digital. Per quanto riguarda Turisanda e il cluster Specialties & goal oriented, infine, l?obiettivo sarà quello di avvicinare chi è alla ricerca di un?offerta tailor made non necessariamente dedicata esclusivamente a portafogli importanti. E ciò anche grazie alla presenza delle line Presstour e Made?.
Ora non resta che capire l?efficacia di un investimento tanto importante. Ed ecco allora che Alpitour ha già avviato, in collaborazione con Wavemaker, una rilevazione ad hoc per misurare il grado di notorietà e consideration dei marchi del gruppo. L?analisi verrà poi ripetuta al termine del primo bimestre di campagna Alpitour e alla fine del secondo, proprio per capire come e quanto muterà il percepito dei brand tra i consumatori.
 
 

We  would love to  say thanks to the author of this  write-up for this  amazing  material



Alpitour: “Io in un villaggio? Mai!”. Parte una campagna da 4 mln di euro


                    [date_timestamp] => 1651207437
                )

            [2] => Array
                (
                    [title] => Nourrir des « chats » quantiques pour doper les calculs
                    [link] => https://moustachebrothers.com/sciences/nourrir-des-chats-quantiques-pour-doper-les-calculs/
                    [dc] => Array
                        (
                            [creator] => Paula Hooper
                        )

                    [pubdate] => Fri, 29 Apr 2022 04:25:25 +0000
                    [category] => SciencescalculschatsdesdoperLesNourrirpourquantiques
                    [guid] => https://moustachebrothers.com/?p=36630
                    [description] => Courageux ? Téméraires ? Inconscients ? Comment qualifier les fondateurs d?une start-up française qui entend rivaliser avec Amazon ? Certes, Alice & Bob, créée en 2020 et installée dans le 15e arrondissement de Paris, ne veut pas concurrencer le géant américain sur la vente en ligne. Elle vise à réaliser ce que sa rivale ne sait pas encore faire. Ni personne ... Read more
                    [content] => Array
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                            [encoded] => 

Courageux ? Téméraires ? Inconscients ? Comment qualifier les fondateurs d?une start-up française qui entend rivaliser avec Amazon ? Certes, Alice & Bob, créée en 2020 et installée dans le 15e arrondissement de Paris, ne veut pas concurrencer le géant américain sur la vente en ligne. Elle vise à réaliser ce que sa rivale ne sait pas encore faire. Ni personne d?autre : un ordinateur quantique.
Ce type de machine est censé accélérer certains calculs, voire en rendre possibles certains autres, jugés infaisables même avec les superordinateurs actuels. La finance, la chimie et l?industrie pharmaceutique, les secteurs de l?énergie et du transport en attendent des merveilles. Les grands de l?informatique, Google, IBM, Microsoft, et les principaux pays (Chine et Etats-Unis en tête) y investissent des milliards. Laboratoires, start-up, grandes entreprises rivalisent pour y parvenir en premier.

Les qubits, pour bits quantiques, remplacent les bits informatiques

Alice & Bob, l?une des dernières lancées dans la course, a levé en mars 27 millions d?euros, apportés par les fonds Elaia, BPI France et Supernova Invest. Soutenue par le CNRS, dont elle est issue, et par le Commissariat à l?énergie atomique, qui participe à la réalisation de ses puces électroniques, elle se distingue par sa manière originale, reprise par Amazon quelque mois après la création de la start-up, de réaliser son objectif. « Je suis passionné de physique et d?électronique et donc très motivé pour inventer et essayer de nouvelles règles du jeu », témoigne Théau Peronnin, polytechnicien, cofondateur de la start-up de 40 personnes avec Raphaël Lescanne, normalien, qu?il a connu pendant sa thèse. Son ambition est de domestiquer un chat? quantique.
« Domestiquer le chat »
L?expression est à prendre au second degré. C?est une métaphore pour vulgariser la propriété d?un objet à être simultanément dans deux états à la fois, 0 et 1 dans le langage informatique, ou mort et vivant, selon les mots d?Erwin Schrödinger, un des pères de la mécanique quantique et auteur de l?image du chat. Cette capacité est la clé de l?accélération promise, car, en autorisant plusieurs états simultanés, elle permet une sorte de parallélisation des calculs. Les qubits, pour bits quantiques, remplacent les bits informatiques.
Créer un tel chat n?est pas si difficile. Prenez un four micro-ondes (avec des parois en niobium), puis miniaturisez-le sur quelques millimètres. A l?intérieur, les photons micro-ondes sont comme des balançoires faisant des allers-retours entre les parois. Deux de ces oscillateurs sont sélectionnés de telle sorte que, quand une balançoire est à son sommet vers l?avant, l?autre est à son plus haut, vers l?arrière. Quelques efforts supplémentaires, et les ingénieurs mélangent ces deux états pour former un chat de Schrödinger : impossible alors de savoir sur quelle balançoire jouent les photons. C?est un qubit de chat.
Il vous reste 52.4% de cet article à lire. La suite est réservée aux abonnés.

We  want to  say thanks to the author of this  post for this  amazing  web content



Nourrir des « chats » quantiques pour doper les calculs


                        )

                    [summary] => Courageux ? Téméraires ? Inconscients ? Comment qualifier les fondateurs d?une start-up française qui entend rivaliser avec Amazon ? Certes, Alice & Bob, créée en 2020 et installée dans le 15e arrondissement de Paris, ne veut pas concurrencer le géant américain sur la vente en ligne. Elle vise à réaliser ce que sa rivale ne sait pas encore faire. Ni personne ... Read more
                    [atom_content] => 

Courageux ? Téméraires ? Inconscients ? Comment qualifier les fondateurs d?une start-up française qui entend rivaliser avec Amazon ? Certes, Alice & Bob, créée en 2020 et installée dans le 15e arrondissement de Paris, ne veut pas concurrencer le géant américain sur la vente en ligne. Elle vise à réaliser ce que sa rivale ne sait pas encore faire. Ni personne d?autre : un ordinateur quantique.
Ce type de machine est censé accélérer certains calculs, voire en rendre possibles certains autres, jugés infaisables même avec les superordinateurs actuels. La finance, la chimie et l?industrie pharmaceutique, les secteurs de l?énergie et du transport en attendent des merveilles. Les grands de l?informatique, Google, IBM, Microsoft, et les principaux pays (Chine et Etats-Unis en tête) y investissent des milliards. Laboratoires, start-up, grandes entreprises rivalisent pour y parvenir en premier.

Les qubits, pour bits quantiques, remplacent les bits informatiques

Alice & Bob, l?une des dernières lancées dans la course, a levé en mars 27 millions d?euros, apportés par les fonds Elaia, BPI France et Supernova Invest. Soutenue par le CNRS, dont elle est issue, et par le Commissariat à l?énergie atomique, qui participe à la réalisation de ses puces électroniques, elle se distingue par sa manière originale, reprise par Amazon quelque mois après la création de la start-up, de réaliser son objectif. « Je suis passionné de physique et d?électronique et donc très motivé pour inventer et essayer de nouvelles règles du jeu », témoigne Théau Peronnin, polytechnicien, cofondateur de la start-up de 40 personnes avec Raphaël Lescanne, normalien, qu?il a connu pendant sa thèse. Son ambition est de domestiquer un chat? quantique.
« Domestiquer le chat »
L?expression est à prendre au second degré. C?est une métaphore pour vulgariser la propriété d?un objet à être simultanément dans deux états à la fois, 0 et 1 dans le langage informatique, ou mort et vivant, selon les mots d?Erwin Schrödinger, un des pères de la mécanique quantique et auteur de l?image du chat. Cette capacité est la clé de l?accélération promise, car, en autorisant plusieurs états simultanés, elle permet une sorte de parallélisation des calculs. Les qubits, pour bits quantiques, remplacent les bits informatiques.
Créer un tel chat n?est pas si difficile. Prenez un four micro-ondes (avec des parois en niobium), puis miniaturisez-le sur quelques millimètres. A l?intérieur, les photons micro-ondes sont comme des balançoires faisant des allers-retours entre les parois. Deux de ces oscillateurs sont sélectionnés de telle sorte que, quand une balançoire est à son sommet vers l?avant, l?autre est à son plus haut, vers l?arrière. Quelques efforts supplémentaires, et les ingénieurs mélangent ces deux états pour former un chat de Schrödinger : impossible alors de savoir sur quelle balançoire jouent les photons. C?est un qubit de chat.
Il vous reste 52.4% de cet article à lire. La suite est réservée aux abonnés.

We  want to  say thanks to the author of this  post for this  amazing  web content



Nourrir des « chats » quantiques pour doper les calculs


                    [date_timestamp] => 1651206325
                )

            [3] => Array
                (
                    [title] => Il Mago di Oz, in vendita all?asta il famoso abito di Judy Garland
                    [link] => https://moustachebrothers.com/shows/il-mago-di-oz-in-vendita-allasta-il-famoso-abito-di-judy-garland/
                    [dc] => Array
                        (
                            [creator] => Sally Scully
                        )

                    [pubdate] => Fri, 29 Apr 2022 04:21:24 +0000
                    [category] => ShowsabitoallastafamosoGarlandJudyMagovendita
                    [guid] => https://moustachebrothers.com/?p=36624
                    [description] => 
 
 
 
 Somewhere over the rainbow. Da qualche parte oltre l’arcobaleno. Proprio così recita la colonna sonora del film ‘Il Mago di Oz‘ e proprio lì doveva essersi cacciato per tutti questi anni il celebre abito bianco e celeste di Dorothy Gale alias Judy Garland.   Leggi anche > Disney+, tutte le serie tv in uscita a ... Read more
                    [content] => Array
                        (
                            [encoded] => 



                


                                


                

Somewhere over the rainbow. Da qualche parte oltre l’arcobaleno. Proprio così recita la colonna sonora del film ‘Il Mago di Oz‘ e proprio lì doveva essersi cacciato per tutti questi anni il celebre abito bianco e celeste di Dorothy Gale alias Judy Garland.
 
Leggi anche > Disney+, tutte le serie tv in uscita a maggio 2022
 


 
Il Mago di Oz, in vendita all’asta il famoso abito di Judy Garland
Dopo oltre 80 anni dall’uscita della pellicola sul grande schermo nel 1939, il vestito che si credeva smarrito per sempre è stato ritrovato e il prossimo mese sarà venduto all’asta. A renderlo noto è il magazine Town&Country che ricostruisce l’avventurosa vicenda di questo costume di scena e del suo fortunoso ritrovamento lo scorso anno.
Come racconta la testata, la storia incomincia nel 1973 quando l’attrice hollywoodiana Mercedes McCambridge decide di donare alla Catholic University of America (CUA) il celebre vestito. L’artista era quasi coetanea di Judy e le due devono essere state presumibilmente amiche, ma non è chiaro come sia entrata in possesso dell’indumento. Tuttavia a partire dal 1980 si perde ogni traccia del prezioso abito, che salta fuori del tutto casualmente solo dopo 40 anni, nel 2021.
«Avevo guardato nei nostri archivi, armadi, ecc. senza alcun risultato» ha spiegato il docente Matt Ripa. «[Io] supponevo che fosse una “leggenda”. Il nostro edificio è in fase di ristrutturazione e aggiornamenti, quindi stavo pulendo il mio ufficio per prepararmi. Ho notato in cima alle cassette postali della facoltà un sacchetto della spazzatura e ho chiesto al mio collega di consegnarmelo. Sul cestino c’era un biglietto che diceva che qualcuno aveva trovato “questo” nel suo ufficio e che doveva averlo spostato quando si era trasferito. Ero curioso di sapere cosa c’era dentro: ho aperto il sacchetto della spazzatura, dentro c’era una scatola da scarpe e all’interno della scatola delle scarpe c’era il vestito! Non potevo crederci».
Presentato alla casa d’aste Bonhams Classic Hollywood: Film and Television sale di Los Angeles per la vendita, l’abito è stato stimato tra gli 800mila dollari e 1,2 milioni di dollari. Secondo Bonhams, il vestito è stato «scelto per una specifica scena dell’amato film, vale a dire quando Dorothy affronta la Strega Malvagia dell’Ovest [interpretata da Margaret Hamilton, ndr] nel Castello delle Streghe».
Quando si terrà l’asta
«Scoprire questo abito storico è stato un momento memorabile per la Catholic University of America e siamo orgogliosi di presentarlo all’asta, in modo che il prossimo collezionista possa possedere un pezzo di storia» ha detto Jacqueline J. Leary-Warsaw, preside della Benjamin T. Rome School of Music, Drama, and Art, in un comunicato stampa. Attualmente l’abito “Dorothy” di Judy Garland è in mostra al Bonhams di New York e dal 20 al 24 maggio sarà visibile al Bonhams di Los Angeles prima che venga messo all’asta il 24 maggio.
Separarsi da questo pezzo di storia del cinema è una sensazione «dolceamara», spiega la professoressa, ma «il ricavato contribuirà a sostenere la formazione delle generazioni future per le carriere professionali nel teatro» a beneficio del Dipartimento Drammatico della CUA. E chissà che proprio il denaro raccolto non contribuisca a finanziare gli studi della futura Judy Garland!
                








                Ultimo aggiornamento: Giovedì 28 Aprile 2022, 22:27


                



                


                  © RIPRODUZIONE RISERVATA            
We  want to thank the author of this  short article for this awesome  web content



Il Mago di Oz, in vendita all’asta il famoso abito di Judy Garland


                        )

                    [summary] => 
 
 
 
 Somewhere over the rainbow. Da qualche parte oltre l’arcobaleno. Proprio così recita la colonna sonora del film ‘Il Mago di Oz‘ e proprio lì doveva essersi cacciato per tutti questi anni il celebre abito bianco e celeste di Dorothy Gale alias Judy Garland.   Leggi anche > Disney+, tutte le serie tv in uscita a ... Read more
                    [atom_content] => 



                


                                


                

Somewhere over the rainbow. Da qualche parte oltre l’arcobaleno. Proprio così recita la colonna sonora del film ‘Il Mago di Oz‘ e proprio lì doveva essersi cacciato per tutti questi anni il celebre abito bianco e celeste di Dorothy Gale alias Judy Garland.
 
Leggi anche > Disney+, tutte le serie tv in uscita a maggio 2022
 


 
Il Mago di Oz, in vendita all’asta il famoso abito di Judy Garland
Dopo oltre 80 anni dall’uscita della pellicola sul grande schermo nel 1939, il vestito che si credeva smarrito per sempre è stato ritrovato e il prossimo mese sarà venduto all’asta. A renderlo noto è il magazine Town&Country che ricostruisce l’avventurosa vicenda di questo costume di scena e del suo fortunoso ritrovamento lo scorso anno.
Come racconta la testata, la storia incomincia nel 1973 quando l’attrice hollywoodiana Mercedes McCambridge decide di donare alla Catholic University of America (CUA) il celebre vestito. L’artista era quasi coetanea di Judy e le due devono essere state presumibilmente amiche, ma non è chiaro come sia entrata in possesso dell’indumento. Tuttavia a partire dal 1980 si perde ogni traccia del prezioso abito, che salta fuori del tutto casualmente solo dopo 40 anni, nel 2021.
«Avevo guardato nei nostri archivi, armadi, ecc. senza alcun risultato» ha spiegato il docente Matt Ripa. «[Io] supponevo che fosse una “leggenda”. Il nostro edificio è in fase di ristrutturazione e aggiornamenti, quindi stavo pulendo il mio ufficio per prepararmi. Ho notato in cima alle cassette postali della facoltà un sacchetto della spazzatura e ho chiesto al mio collega di consegnarmelo. Sul cestino c’era un biglietto che diceva che qualcuno aveva trovato “questo” nel suo ufficio e che doveva averlo spostato quando si era trasferito. Ero curioso di sapere cosa c’era dentro: ho aperto il sacchetto della spazzatura, dentro c’era una scatola da scarpe e all’interno della scatola delle scarpe c’era il vestito! Non potevo crederci».
Presentato alla casa d’aste Bonhams Classic Hollywood: Film and Television sale di Los Angeles per la vendita, l’abito è stato stimato tra gli 800mila dollari e 1,2 milioni di dollari. Secondo Bonhams, il vestito è stato «scelto per una specifica scena dell’amato film, vale a dire quando Dorothy affronta la Strega Malvagia dell’Ovest [interpretata da Margaret Hamilton, ndr] nel Castello delle Streghe».
Quando si terrà l’asta
«Scoprire questo abito storico è stato un momento memorabile per la Catholic University of America e siamo orgogliosi di presentarlo all’asta, in modo che il prossimo collezionista possa possedere un pezzo di storia» ha detto Jacqueline J. Leary-Warsaw, preside della Benjamin T. Rome School of Music, Drama, and Art, in un comunicato stampa. Attualmente l’abito “Dorothy” di Judy Garland è in mostra al Bonhams di New York e dal 20 al 24 maggio sarà visibile al Bonhams di Los Angeles prima che venga messo all’asta il 24 maggio.
Separarsi da questo pezzo di storia del cinema è una sensazione «dolceamara», spiega la professoressa, ma «il ricavato contribuirà a sostenere la formazione delle generazioni future per le carriere professionali nel teatro» a beneficio del Dipartimento Drammatico della CUA. E chissà che proprio il denaro raccolto non contribuisca a finanziare gli studi della futura Judy Garland!
                








                Ultimo aggiornamento: Giovedì 28 Aprile 2022, 22:27


                



                


                  © RIPRODUZIONE RISERVATA            
We  want to thank the author of this  short article for this awesome  web content



Il Mago di Oz, in vendita all’asta il famoso abito di Judy Garland


                    [date_timestamp] => 1651206084
                )

            [4] => Array
                (
                    [title] => Higher COVID-19 death rates in the southern U.S. due to behavior variations, study finds
                    [link] => https://moustachebrothers.com/healthandscience/higher-covid-19-death-rates-in-the-southern-u-s-due-to-behavior-variations-study-finds/
                    [dc] => Array
                        (
                            [creator] => Tony Grantly
                        )

                    [pubdate] => Fri, 29 Apr 2022 03:43:12 +0000
                    [category] => Health And SciencebehaviorCovid19deathRatessouthernstudyvariations
                    [guid] => https://moustachebrothers.com/?p=36619
                    [description] => Journal Reference: Michael A. Stoto, Samantha Schlageter, John D. Kraemer. COVID-19 mortality in the United States: It?s been two Americas from the start. PLOS ONE, 2022; 17 (4): e0265053 DOI: 10.1371/journal.pone.0265053 The study, by Georgetown University?s School of Nursing & Health Studies researchers, appeared April 28, 2022, in PLOS ONE. Excess mortality, which helps account ... Read more
                    [content] => Array
                        (
                            [encoded] => 

Journal Reference:

Michael A. Stoto, Samantha Schlageter, John D. Kraemer. COVID-19 mortality in the United States: It?s been two Americas from the start. PLOS ONE, 2022; 17 (4): e0265053 DOI: 10.1371/journal.pone.0265053


The study, by Georgetown University?s School of Nursing & Health Studies researchers, appeared April 28, 2022, in PLOS ONE.
Excess mortality, which helps account for avoidable deaths from a new disease or situation, is defined by the difference between total current deaths and deaths expected based on earlier time period, usually the previous decade or so. The U.S. Centers for Disease Control and Prevention (CDC) calculates these numbers weekly. For this study, the CDC excess mortality data were analyzed for the period between January 3, 2020, to September 26, 2021. For regional comparison purposes, areas of the country were broken down into the Northeast, Midwest, South and West.
?Our goal was to carefully examine regional differences in COVID-19 death rates based on reliable statistical data,? says Michael Stoto, Ph.D., professor of Health Systems Administration and Population Health at the School of Nursing & Health Studies and corresponding author of the study. ?Our study is the first to quantify avoidable deaths and confirm that both COVID-19 deaths and avoidable deaths disproportionately occurred in the South.?
The investigators found that regional differences in COVID-19 mortality rates have persisted throughout the pandemic. The southern part of the United States has had higher mortality rates than the rest of the U.S. since the start of summer in 2020. Since October 2020, 48% of COVID-19 deaths were in the South, which makes up 38% of the population, pointing to disproportionate outcomes regionally.
The researchers also determined that between January 2020 and September 2021 there were 895,693 excess deaths associated with COVID-19, which is 26% more than reported by other experts who track disease. Although the official total neared on one million deaths in the U.S due to COVID-19 by late April 2022, based on this undercount the scientists believe that threshold was actually passed at the beginning of 2022.
These estimates of undercounts are important because most studies have looked at excess mortality at the state and county level in the U.S., but because of small population sizes, the studies have not examined patterns over time. Some earlier studies explored the relationship between COVID-19 mortality and age, education, and other factors as well as vaccine uptake, party affiliation, and other factors. But most studies have used reported COVID-19 deaths rather than excess deaths, as compared to what Dr. Stoto and collaborators have done, and may not be as statistically reliable.
?This is one of a series of planned studies to look carefully at the response to COVID-19 in the U.S. and other countries and to learn from the experience in order to strengthen preparedness for future potential outbreaks,? says Stoto. ?Our team has also looked at testing and surveillance, and other COVID-19 metrics to understand how communities have come together to effectively deal with the pandemic.?
In addition to Stoto, the other authors from Georgetown include Samantha Schlageter, who conducted this work as an undergraduate in the Health Care Management & Policy program at the School of Nursing & Health Studies (NHS), and John D. Kraemer, an associate professor in Department of Health Systems Administration at NHS.

We would like to  give thanks to the author of this article for this  remarkable  web content



Higher COVID-19 death rates in the southern U.S. due to behavior variations, study finds


                        )

                    [summary] => Journal Reference: Michael A. Stoto, Samantha Schlageter, John D. Kraemer. COVID-19 mortality in the United States: It?s been two Americas from the start. PLOS ONE, 2022; 17 (4): e0265053 DOI: 10.1371/journal.pone.0265053 The study, by Georgetown University?s School of Nursing & Health Studies researchers, appeared April 28, 2022, in PLOS ONE. Excess mortality, which helps account ... Read more
                    [atom_content] => 

Journal Reference:

Michael A. Stoto, Samantha Schlageter, John D. Kraemer. COVID-19 mortality in the United States: It?s been two Americas from the start. PLOS ONE, 2022; 17 (4): e0265053 DOI: 10.1371/journal.pone.0265053


The study, by Georgetown University?s School of Nursing & Health Studies researchers, appeared April 28, 2022, in PLOS ONE.
Excess mortality, which helps account for avoidable deaths from a new disease or situation, is defined by the difference between total current deaths and deaths expected based on earlier time period, usually the previous decade or so. The U.S. Centers for Disease Control and Prevention (CDC) calculates these numbers weekly. For this study, the CDC excess mortality data were analyzed for the period between January 3, 2020, to September 26, 2021. For regional comparison purposes, areas of the country were broken down into the Northeast, Midwest, South and West.
?Our goal was to carefully examine regional differences in COVID-19 death rates based on reliable statistical data,? says Michael Stoto, Ph.D., professor of Health Systems Administration and Population Health at the School of Nursing & Health Studies and corresponding author of the study. ?Our study is the first to quantify avoidable deaths and confirm that both COVID-19 deaths and avoidable deaths disproportionately occurred in the South.?
The investigators found that regional differences in COVID-19 mortality rates have persisted throughout the pandemic. The southern part of the United States has had higher mortality rates than the rest of the U.S. since the start of summer in 2020. Since October 2020, 48% of COVID-19 deaths were in the South, which makes up 38% of the population, pointing to disproportionate outcomes regionally.
The researchers also determined that between January 2020 and September 2021 there were 895,693 excess deaths associated with COVID-19, which is 26% more than reported by other experts who track disease. Although the official total neared on one million deaths in the U.S due to COVID-19 by late April 2022, based on this undercount the scientists believe that threshold was actually passed at the beginning of 2022.
These estimates of undercounts are important because most studies have looked at excess mortality at the state and county level in the U.S., but because of small population sizes, the studies have not examined patterns over time. Some earlier studies explored the relationship between COVID-19 mortality and age, education, and other factors as well as vaccine uptake, party affiliation, and other factors. But most studies have used reported COVID-19 deaths rather than excess deaths, as compared to what Dr. Stoto and collaborators have done, and may not be as statistically reliable.
?This is one of a series of planned studies to look carefully at the response to COVID-19 in the U.S. and other countries and to learn from the experience in order to strengthen preparedness for future potential outbreaks,? says Stoto. ?Our team has also looked at testing and surveillance, and other COVID-19 metrics to understand how communities have come together to effectively deal with the pandemic.?
In addition to Stoto, the other authors from Georgetown include Samantha Schlageter, who conducted this work as an undergraduate in the Health Care Management & Policy program at the School of Nursing & Health Studies (NHS), and John D. Kraemer, an associate professor in Department of Health Systems Administration at NHS.

We would like to  give thanks to the author of this article for this  remarkable  web content



Higher COVID-19 death rates in the southern U.S. due to behavior variations, study finds


                    [date_timestamp] => 1651203792
                )

            [5] => Array
                (
                    [title] => Scientists call for cap on production to end plastic pollution
                    [link] => https://moustachebrothers.com/healthandscience/scientists-call-for-cap-on-production-to-end-plastic-pollution/
                    [dc] => Array
                        (
                            [creator] => Tony Grantly
                        )

                    [pubdate] => Fri, 29 Apr 2022 02:26:08 +0000
                    [category] => Health And SciencecapplasticpollutionProductionscientists
                    [guid] => https://moustachebrothers.com/?p=36614
                    [description] => Journal Reference: Melanie Bergmann, Bethanie Carney Almroth, Susanne M. Brander, Tridibesh Dey, Dannielle S. Green, Sedat Gundogdu, Anja Krieger, Martin Wagner, Tony R. Walker. A global plastic treaty must cap production. Science, 2022; 376 (6592): 469 DOI: 10.1126/science.abq0082 Now, after the United Nations? historic decision to adopt a global treaty to end plastic pollution earlier ... Read more
                    [content] => Array
                        (
                            [encoded] => 

Journal Reference:

Melanie Bergmann, Bethanie Carney Almroth, Susanne M. Brander, Tridibesh Dey, Dannielle S. Green, Sedat Gundogdu, Anja Krieger, Martin Wagner, Tony R. Walker. A global plastic treaty must cap production. Science, 2022; 376 (6592): 469 DOI: 10.1126/science.abq0082


Now, after the United Nations? historic decision to adopt a global treaty to end plastic pollution earlier this year, governmental negotiations on the agreement are set to begin on May 30th. These will foster intense debates on what kind of measures will be needed to end the pollution of the air, soils, rivers and oceans with plastic debris and microplastics.
In a letter to the journal Science, an international group of scientists and experts now argue for tackling the issue right at the source, by regulating, capping, and in the long term phasing out the production of new plastics.
Recycling not enough
?Even if we recycled better and tried to manage the waste as much as we can, we would still release more than 17 million tons of plastic per year into nature,? says Melanie Bergmann of the German Alfred-Wegener-Institute, the initiator of the letter. ?If production just keeps growing and growing, we will be faced with a truly Sisyphean task,? she adds.
Research published in Science in 2020 shows that plastic emissions can only be cut by 79 per cent over the next 20 years if all solutions available today are implemented, including replacing some plastics with other materials, and improved recycling and waste management.
?The exponentially growing production is really the root cause of the problem, and the amounts of plastics we have produced thus far have already exceeded planetary boundaries,? says Bethanie Carney Almroth of the University of Gothenburg, Sweden. ?If we don?t tackle that, all other measures will fail to achieve the goal of substantially reducing the release of plastic into the environment,? she said.
Phasing out new plastics important
Phasing out the production of new plastics from fresh feedstocks should be part of a systemic solution to end plastic pollution, the experts from Canada, Germany, India, Norway, Sweden, Turkey, the UK and the U.S. argue. This approach is supported by the best science available today and in line with what political and legal experts proposed in Science last year.
Along with measures to address the consumption and demand side of the problem ? such as taxes ? a comprehensive approach must also cover the supply side, meaning the actual amount of plastics produced and put on the market.
Gradually cutting the production of new plastics will come with many societal, environmental and economic benefits, the scientists say.
Sedat Gündo?du of the Cukurova University, Turkey, says ?The massive production also feeds the plastic waste transfer from the Global North to the South. A production cap will facilitate getting rid of non-essential applications and reduce plastic waste exports.?
?We gain a lot of benefits from plastics but reducing production will increase the value of plastics, boost other measures to curb plastic pollution, help tackle climate change and promote our transition to a circular and sustainable economy,? adds Martin Wagner, an ecotoxicologist at the Norwegian University of Science and Technology.

We  wish to thank the  writer of this  write-up for this awesome content



Scientists call for cap on production to end plastic pollution


                        )

                    [summary] => Journal Reference: Melanie Bergmann, Bethanie Carney Almroth, Susanne M. Brander, Tridibesh Dey, Dannielle S. Green, Sedat Gundogdu, Anja Krieger, Martin Wagner, Tony R. Walker. A global plastic treaty must cap production. Science, 2022; 376 (6592): 469 DOI: 10.1126/science.abq0082 Now, after the United Nations? historic decision to adopt a global treaty to end plastic pollution earlier ... Read more
                    [atom_content] => 

Journal Reference:

Melanie Bergmann, Bethanie Carney Almroth, Susanne M. Brander, Tridibesh Dey, Dannielle S. Green, Sedat Gundogdu, Anja Krieger, Martin Wagner, Tony R. Walker. A global plastic treaty must cap production. Science, 2022; 376 (6592): 469 DOI: 10.1126/science.abq0082


Now, after the United Nations? historic decision to adopt a global treaty to end plastic pollution earlier this year, governmental negotiations on the agreement are set to begin on May 30th. These will foster intense debates on what kind of measures will be needed to end the pollution of the air, soils, rivers and oceans with plastic debris and microplastics.
In a letter to the journal Science, an international group of scientists and experts now argue for tackling the issue right at the source, by regulating, capping, and in the long term phasing out the production of new plastics.
Recycling not enough
?Even if we recycled better and tried to manage the waste as much as we can, we would still release more than 17 million tons of plastic per year into nature,? says Melanie Bergmann of the German Alfred-Wegener-Institute, the initiator of the letter. ?If production just keeps growing and growing, we will be faced with a truly Sisyphean task,? she adds.
Research published in Science in 2020 shows that plastic emissions can only be cut by 79 per cent over the next 20 years if all solutions available today are implemented, including replacing some plastics with other materials, and improved recycling and waste management.
?The exponentially growing production is really the root cause of the problem, and the amounts of plastics we have produced thus far have already exceeded planetary boundaries,? says Bethanie Carney Almroth of the University of Gothenburg, Sweden. ?If we don?t tackle that, all other measures will fail to achieve the goal of substantially reducing the release of plastic into the environment,? she said.
Phasing out new plastics important
Phasing out the production of new plastics from fresh feedstocks should be part of a systemic solution to end plastic pollution, the experts from Canada, Germany, India, Norway, Sweden, Turkey, the UK and the U.S. argue. This approach is supported by the best science available today and in line with what political and legal experts proposed in Science last year.
Along with measures to address the consumption and demand side of the problem ? such as taxes ? a comprehensive approach must also cover the supply side, meaning the actual amount of plastics produced and put on the market.
Gradually cutting the production of new plastics will come with many societal, environmental and economic benefits, the scientists say.
Sedat Gündo?du of the Cukurova University, Turkey, says ?The massive production also feeds the plastic waste transfer from the Global North to the South. A production cap will facilitate getting rid of non-essential applications and reduce plastic waste exports.?
?We gain a lot of benefits from plastics but reducing production will increase the value of plastics, boost other measures to curb plastic pollution, help tackle climate change and promote our transition to a circular and sustainable economy,? adds Martin Wagner, an ecotoxicologist at the Norwegian University of Science and Technology.

We  wish to thank the  writer of this  write-up for this awesome content



Scientists call for cap on production to end plastic pollution


                    [date_timestamp] => 1651199168
                )

            [6] => Array
                (
                    [title] => Gene mutations that contribute to head and neck cancer also provide ?precision? treatment targets
                    [link] => https://moustachebrothers.com/healthandscience/gene-mutations-that-contribute-to-head-and-neck-cancer-also-provide-precision-treatment-targets/
                    [dc] => Array
                        (
                            [creator] => Tony Grantly
                        )

                    [pubdate] => Fri, 29 Apr 2022 01:09:11 +0000
                    [category] => Health And SciencecancercontributegeneMutationsneckPrecisionprovidetargetstreatment
                    [guid] => https://moustachebrothers.com/?p=36609
                    [description] => Journal Reference: Hoi-Lam Ngan, Chun-Ho Law, Yannie Chung Yan Choi, Jenny Yu-Sum Chan, Vivian Wai Yan Lui. Precision drugging of the MAPK pathway in head and neck cancer. npj Genomic Medicine, 2022; 7 (1) DOI: 10.1038/s41525-022-00293-1 Keys to targeting that vulnerability include individualized genomic analysis to identify a patient?s specific mutation, and finding the drugs ... Read more
                    [content] => Array
                        (
                            [encoded] => 

Journal Reference:

Hoi-Lam Ngan, Chun-Ho Law, Yannie Chung Yan Choi, Jenny Yu-Sum Chan, Vivian Wai Yan Lui. Precision drugging of the MAPK pathway in head and neck cancer. npj Genomic Medicine, 2022; 7 (1) DOI: 10.1038/s41525-022-00293-1


Keys to targeting that vulnerability include individualized genomic analysis to identify a patient?s specific mutation, and finding the drugs that directly target it, investigations that should be given more attention in cancer therapy development, they report in a review article in the journal NPJ Genomic Medicine.
The MAPK pathway is a ?signaling hub? for cells important to the usual development of the head and neck region, and activating key pathway constituents, like the genes MAPK1 and HRAS, is known to drive the growth of a variety of cancers, says Dr. Vivian Wai Yan Lui, molecular pharmacologist and translational scientist at the Georgia Cancer Center and Medical College of Georgia and the paper?s corresponding author.
But the mutations in the genes in the MAPK pathway that enable tumor growth can also make it sensitive to drug therapy, says Lui. While a lot of discovery is still needed to find more mutations in the MAPK pathway and the drugs that target them, Lui says they are among the most logical treatment targets for this tough-to-treat cancer.
As she speaks, she is looking in her lab for drugs that kill head and neck primary tumors from patients, and at the genetics behind how they kill.
?It?s critical to the survival of the cancer,? says Lui, and every cancer type likely has one or more drug-sensitizing mutations that may vary in individuals depending on how they got cancer.
If these types of studies continue to find the methodology works, gene panels might need to be developed to expedite target discovery in this very heterogenous cancer, the scientists write.
More clinical trials around the globe at institutions like MCG and the Georgia Cancer Center are essential to identifying these specific mutations and drugs that target them in a precision manner, Lui notes.
Also, next on the horizon is combining this ?precision medicine? approach with immunotherapy that better enables a patient?s immune system to also target the cancer, she says.
Lui?s interest in the MAPK pathway solidified almost a decade ago at the University of Pittsburgh where she did her postdoctoral studies and eventually joined the faculty. Her mentor was Dr. Jennifer R. Grandis (now at the University of California, San Francisco), who led the head and neck cancer program there. The patient in his 30s, a heavy smoker and drinker, had stage four head and neck squamous cell carcinoma that had metastasized to his lymph nodes. The patient went to Pittsburgh for removal of the lymph nodes and the primary tumor but was fortunate enough to be eligible for a ?window of opportunity? trial there. Before starting any standard treatment, he received a trial drug for 13 days, in his case an epidermal growth factor receptor, or EGFR, blocker. The receptor is involved in cell growth, and is found on some normal cells, including in the head and neck area where there is a lot of natural cell turnover because of exposure to things like food and drink. However, in cancer cells, including head and neck cancer cells, EGFR is abundantly expressed for the rapid growth critical to a tumor?s spread and survival.
The patient was given the drug, erlotinib, which was not known to be particularly effective in these cancers but was being looked at to see if it would quieten signaling of this factor that was important to the cancer?s growth. When he went for surgery following the trial, the surgeon called to report there was no cancer on his tongue and studies of his 36 lymph nodes indicated they also now showed no evidence of cancer. The patient was still doing well by the time the Pittsburgh colleagues published the paper two years later in 2015 in JAMA Oncology.
His was rightly called an ?exceptional response,? the first Lui and her colleagues had found in head and neck cancer, and she had to figure out the mutation the drug targeted to enable such a response. Exceptional responders are how the National Cancer Institute describes people who have more than a six-month response to a therapy when they are running out of treatment options.
An EGFR gene mutation was a logical choice for his mutation. Harvard investigators had previously found that in non-small cell lung cancer, EGFR activating mutations could activate tumor cell growth, which also made tumor cells ?addicted? to the signal from the mutated EGFR. The drug erlotinib could break the addiction and inhibit cancer cell growth.
Lui didn?t find an EGFR mutation in this young man?s pretreatment biopsy but reasoned the mutation had to have something to do with the receptor?s signaling network. She was surprised ? and the first ? to find it was a MAPK1 gene mutation, MAPK1 p.E322K specifically, that could also be found in liver, breast and other cancers.
When they later engineered the mutation in head and neck cancer cells, the already aggressive cells grew even faster, Lui says of a mutation that can result from habits like heavy smoking and drinking. They would also find that the particular mutation was very common in the United States in patients with head and neck cancer, while there was a wider spectrum of mutations present in Asians with the cancer.
Erlotinib had actually failed in clinical trials because it wasn?t given to the right patients, which is what precision medicine is, Lui notes. In fact, laboratory studies had indicated that activation of MAPK1 confers resistance to erlotinib, she says, while this patient?s response clearly counters that. Follow up work by Grandis indicated that in patients actually, the higher the MAPK1 activation, the better the cancer responded to erlotinib.
To help move cancer treatment forward, Lui encourages physicians who come across these types of ?exceptional responses? to report them, work with scientists to study them, then pursue clinical trials when appropriate.
For patients, her message is not to give up because with more high-level analysis of tumors, there might be a certain mutation that makes their cancer vulnerable to a specific medication, she says of these ?gene-drug responses? that are the focal point of her translational work.
?There are secrets that make the cancer vulnerable,? Lui says. ?When cancer cells have an important gene mutation that they are activating or that cancer cells are addicted to for survival, then when you hit that signaling pathway, the cancer cells will die or be really well controlled.?
Prior to the era of genomic medicine, when scientists began to identify and target a specific gene mutation, ?non-precision? drug treatment of the MAPK pathway in head and neck cancers as well as other cancers were ?futile,? and typically ?failed miserably? in clinical trials, Lui and her colleagues write.
While the reasons may be uncertain, they likely include the wrong drug for that specific, problematic mutation, Lui says, as well as the fact that some MAPK pathway mutations are known to convey drug resistance.
Either way, there is a lot of work to do. Today there are just a handful of drugs that target specific, cancer-causing mutations in head and neck cancer but there aren?t effective precision drugs for about 80% of patients, Lui and her coauthors write.
But there is mounting evidence that targeting specific MAPK pathway mutations in the pathway like MAPK1, HRAS, KRAS and BRAF can be very effective for these patients.
As an example, the RAS inhibitor tipifarnib received Breakthrough Therapy Designation by the Food and Drug Administration in February 2021 for patients with a specific recurrent or metastatic HRAS-mutant head and neck squamous cell cancer. HRAS is involved in cell growth signaling.
Also, studies indicate that EGFR targeted therapy in metastatic non-small cell lung cancer, increases progression-free survival to a median of 18.9 months and median overall survival beyond three years and reduces death rates about 52%. In 2016 the Food and Drug Administration modified its approval of erlotinib to treat non-small cell lung cancer patients with the specific EGFR mutations. In 2020, the FDA approved erlotinib in combination with ramucirumab, a monoclonal antibody that binds to a receptor for vascular endothelial growth factor, or VEGF, which tumors use to grow the blood vessels they need to thrive, as a frontline treatment for these cancers. The FDA granted Breakthrough Therapy Designation to tipifarnib, an inhibitor of a protein which has the downstream effect of interfering in this case with mutations of the gene HRAS, which is also involved in cell division and in the MAPK pathway. There are now more than 1.5 million people with non-small cell lung cancer on precision medicine because of investigators who continued to examine the initial few responders, Lui says.
Lui is a native of Hong Kong, who was on the faculty of The Chinese University of Hong Kong before joining the MCG faculty in October 2021. In 2020 Lui and her colleagues reported that MAPK pathway mutations are a factor in about one-fifth of head and neck cancer patients and that ?unexpectedly? these mutations are associated with longer patient survival than other causes like human papillomavirus.
Head and neck cancer is typically aggressive and often both the disease and its treatment are painful and disfiguring. It carries a higher risk of suicide than many other cancer types. The incidence of head and neck cancer is going up across the world, with causes including tobacco and/or alcohol use, air pollutants, cancer causing viruses like the sexually transmitted HPV, and Epstein-Barr virus, one of the most common viruses that is primarily spread by saliva and can cause problems like infectious mononucleosis. Other causes include poor dental hygiene and chewing betel nut, a stimulant which comes from the Areca palm plant, and is used as a recreational drug and as a still-unproven treatment for problems like schizophrenia and glaucoma. Chewing betel nut is a common cultural practice in South and Southeast Asia and the Asian Pacific. It?s often chewed with products like tobacco and has been associated with cancer and a host of other medical problems like a slow heart rate and stomach ulcers.
The carcinogens largely damage the lining of the head and neck region resulting in one or more mutations that can lead to cancer.

We  want to thank the  writer of this article for this  amazing content



Gene mutations that contribute to head and neck cancer also provide ?precision? treatment targets


                        )

                    [summary] => Journal Reference: Hoi-Lam Ngan, Chun-Ho Law, Yannie Chung Yan Choi, Jenny Yu-Sum Chan, Vivian Wai Yan Lui. Precision drugging of the MAPK pathway in head and neck cancer. npj Genomic Medicine, 2022; 7 (1) DOI: 10.1038/s41525-022-00293-1 Keys to targeting that vulnerability include individualized genomic analysis to identify a patient?s specific mutation, and finding the drugs ... Read more
                    [atom_content] => 

Journal Reference:

Hoi-Lam Ngan, Chun-Ho Law, Yannie Chung Yan Choi, Jenny Yu-Sum Chan, Vivian Wai Yan Lui. Precision drugging of the MAPK pathway in head and neck cancer. npj Genomic Medicine, 2022; 7 (1) DOI: 10.1038/s41525-022-00293-1


Keys to targeting that vulnerability include individualized genomic analysis to identify a patient?s specific mutation, and finding the drugs that directly target it, investigations that should be given more attention in cancer therapy development, they report in a review article in the journal NPJ Genomic Medicine.
The MAPK pathway is a ?signaling hub? for cells important to the usual development of the head and neck region, and activating key pathway constituents, like the genes MAPK1 and HRAS, is known to drive the growth of a variety of cancers, says Dr. Vivian Wai Yan Lui, molecular pharmacologist and translational scientist at the Georgia Cancer Center and Medical College of Georgia and the paper?s corresponding author.
But the mutations in the genes in the MAPK pathway that enable tumor growth can also make it sensitive to drug therapy, says Lui. While a lot of discovery is still needed to find more mutations in the MAPK pathway and the drugs that target them, Lui says they are among the most logical treatment targets for this tough-to-treat cancer.
As she speaks, she is looking in her lab for drugs that kill head and neck primary tumors from patients, and at the genetics behind how they kill.
?It?s critical to the survival of the cancer,? says Lui, and every cancer type likely has one or more drug-sensitizing mutations that may vary in individuals depending on how they got cancer.
If these types of studies continue to find the methodology works, gene panels might need to be developed to expedite target discovery in this very heterogenous cancer, the scientists write.
More clinical trials around the globe at institutions like MCG and the Georgia Cancer Center are essential to identifying these specific mutations and drugs that target them in a precision manner, Lui notes.
Also, next on the horizon is combining this ?precision medicine? approach with immunotherapy that better enables a patient?s immune system to also target the cancer, she says.
Lui?s interest in the MAPK pathway solidified almost a decade ago at the University of Pittsburgh where she did her postdoctoral studies and eventually joined the faculty. Her mentor was Dr. Jennifer R. Grandis (now at the University of California, San Francisco), who led the head and neck cancer program there. The patient in his 30s, a heavy smoker and drinker, had stage four head and neck squamous cell carcinoma that had metastasized to his lymph nodes. The patient went to Pittsburgh for removal of the lymph nodes and the primary tumor but was fortunate enough to be eligible for a ?window of opportunity? trial there. Before starting any standard treatment, he received a trial drug for 13 days, in his case an epidermal growth factor receptor, or EGFR, blocker. The receptor is involved in cell growth, and is found on some normal cells, including in the head and neck area where there is a lot of natural cell turnover because of exposure to things like food and drink. However, in cancer cells, including head and neck cancer cells, EGFR is abundantly expressed for the rapid growth critical to a tumor?s spread and survival.
The patient was given the drug, erlotinib, which was not known to be particularly effective in these cancers but was being looked at to see if it would quieten signaling of this factor that was important to the cancer?s growth. When he went for surgery following the trial, the surgeon called to report there was no cancer on his tongue and studies of his 36 lymph nodes indicated they also now showed no evidence of cancer. The patient was still doing well by the time the Pittsburgh colleagues published the paper two years later in 2015 in JAMA Oncology.
His was rightly called an ?exceptional response,? the first Lui and her colleagues had found in head and neck cancer, and she had to figure out the mutation the drug targeted to enable such a response. Exceptional responders are how the National Cancer Institute describes people who have more than a six-month response to a therapy when they are running out of treatment options.
An EGFR gene mutation was a logical choice for his mutation. Harvard investigators had previously found that in non-small cell lung cancer, EGFR activating mutations could activate tumor cell growth, which also made tumor cells ?addicted? to the signal from the mutated EGFR. The drug erlotinib could break the addiction and inhibit cancer cell growth.
Lui didn?t find an EGFR mutation in this young man?s pretreatment biopsy but reasoned the mutation had to have something to do with the receptor?s signaling network. She was surprised ? and the first ? to find it was a MAPK1 gene mutation, MAPK1 p.E322K specifically, that could also be found in liver, breast and other cancers.
When they later engineered the mutation in head and neck cancer cells, the already aggressive cells grew even faster, Lui says of a mutation that can result from habits like heavy smoking and drinking. They would also find that the particular mutation was very common in the United States in patients with head and neck cancer, while there was a wider spectrum of mutations present in Asians with the cancer.
Erlotinib had actually failed in clinical trials because it wasn?t given to the right patients, which is what precision medicine is, Lui notes. In fact, laboratory studies had indicated that activation of MAPK1 confers resistance to erlotinib, she says, while this patient?s response clearly counters that. Follow up work by Grandis indicated that in patients actually, the higher the MAPK1 activation, the better the cancer responded to erlotinib.
To help move cancer treatment forward, Lui encourages physicians who come across these types of ?exceptional responses? to report them, work with scientists to study them, then pursue clinical trials when appropriate.
For patients, her message is not to give up because with more high-level analysis of tumors, there might be a certain mutation that makes their cancer vulnerable to a specific medication, she says of these ?gene-drug responses? that are the focal point of her translational work.
?There are secrets that make the cancer vulnerable,? Lui says. ?When cancer cells have an important gene mutation that they are activating or that cancer cells are addicted to for survival, then when you hit that signaling pathway, the cancer cells will die or be really well controlled.?
Prior to the era of genomic medicine, when scientists began to identify and target a specific gene mutation, ?non-precision? drug treatment of the MAPK pathway in head and neck cancers as well as other cancers were ?futile,? and typically ?failed miserably? in clinical trials, Lui and her colleagues write.
While the reasons may be uncertain, they likely include the wrong drug for that specific, problematic mutation, Lui says, as well as the fact that some MAPK pathway mutations are known to convey drug resistance.
Either way, there is a lot of work to do. Today there are just a handful of drugs that target specific, cancer-causing mutations in head and neck cancer but there aren?t effective precision drugs for about 80% of patients, Lui and her coauthors write.
But there is mounting evidence that targeting specific MAPK pathway mutations in the pathway like MAPK1, HRAS, KRAS and BRAF can be very effective for these patients.
As an example, the RAS inhibitor tipifarnib received Breakthrough Therapy Designation by the Food and Drug Administration in February 2021 for patients with a specific recurrent or metastatic HRAS-mutant head and neck squamous cell cancer. HRAS is involved in cell growth signaling.
Also, studies indicate that EGFR targeted therapy in metastatic non-small cell lung cancer, increases progression-free survival to a median of 18.9 months and median overall survival beyond three years and reduces death rates about 52%. In 2016 the Food and Drug Administration modified its approval of erlotinib to treat non-small cell lung cancer patients with the specific EGFR mutations. In 2020, the FDA approved erlotinib in combination with ramucirumab, a monoclonal antibody that binds to a receptor for vascular endothelial growth factor, or VEGF, which tumors use to grow the blood vessels they need to thrive, as a frontline treatment for these cancers. The FDA granted Breakthrough Therapy Designation to tipifarnib, an inhibitor of a protein which has the downstream effect of interfering in this case with mutations of the gene HRAS, which is also involved in cell division and in the MAPK pathway. There are now more than 1.5 million people with non-small cell lung cancer on precision medicine because of investigators who continued to examine the initial few responders, Lui says.
Lui is a native of Hong Kong, who was on the faculty of The Chinese University of Hong Kong before joining the MCG faculty in October 2021. In 2020 Lui and her colleagues reported that MAPK pathway mutations are a factor in about one-fifth of head and neck cancer patients and that ?unexpectedly? these mutations are associated with longer patient survival than other causes like human papillomavirus.
Head and neck cancer is typically aggressive and often both the disease and its treatment are painful and disfiguring. It carries a higher risk of suicide than many other cancer types. The incidence of head and neck cancer is going up across the world, with causes including tobacco and/or alcohol use, air pollutants, cancer causing viruses like the sexually transmitted HPV, and Epstein-Barr virus, one of the most common viruses that is primarily spread by saliva and can cause problems like infectious mononucleosis. Other causes include poor dental hygiene and chewing betel nut, a stimulant which comes from the Areca palm plant, and is used as a recreational drug and as a still-unproven treatment for problems like schizophrenia and glaucoma. Chewing betel nut is a common cultural practice in South and Southeast Asia and the Asian Pacific. It?s often chewed with products like tobacco and has been associated with cancer and a host of other medical problems like a slow heart rate and stomach ulcers.
The carcinogens largely damage the lining of the head and neck region resulting in one or more mutations that can lead to cancer.

We  want to thank the  writer of this article for this  amazing content



Gene mutations that contribute to head and neck cancer also provide ?precision? treatment targets


                    [date_timestamp] => 1651194551
                )

            [7] => Array
                (
                    [title] => Nicolas Cage is the Most Fascinating and Exciting Actor Working Today
                    [link] => https://moustachebrothers.com/trending-people/nicolas-cage-is-the-most-fascinating-and-exciting-actor-working-today/
                    [dc] => Array
                        (
                            [creator] => Pauline Moonlky
                        )

                    [pubdate] => Fri, 29 Apr 2022 01:02:53 +0000
                    [category] => Trending PeopleActorCageexcitingFascinatingNicolas
                    [guid] => https://moustachebrothers.com/?p=36603
                    [description] => In Nicolas Cage?s latest film, The Unbearable Weight of Massive Talent, Cage plays a character called?Nick Cage. This meta-commentary on fame and celebrity, wrapped around a thriller plot, is full of Cage-inspired ?Easter eggs? and knowing nods to the audience. Once again, Cage reminds us that he might just be the most interesting and exciting ... Read more
                    [content] => Array
                        (
                            [encoded] => 

In Nicolas Cage?s latest film, The Unbearable Weight of Massive Talent, Cage plays a character called?Nick Cage. This meta-commentary on fame and celebrity, wrapped around a thriller plot, is full of Cage-inspired ?Easter eggs? and knowing nods to the audience.
Once again, Cage reminds us that he might just be the most interesting and exciting actor working in mainstream cinema today.
As a Cage super-fan, I?ve always been struck by his prodigious work ethic (over 100 films, many shot back-to-back or concurrently); his appeal to venerated auteurs like David Lynch, Werner Herzog, and Martin Scorsese; his eclectic, quirky choices that bamboozle us; and his approach to stardom.
?
Take three other actors of a similar age: Cage is not Tom Cruise, whose precision-engineered career allows no risks to be taken. Nor is he Jim Carrey, whose early career blazed brightly and then faded away. Nor is he George Clooney, who has traded stardom for activism and advocacy.
Cage?s take on stardom is different: a chance to reinvent himself with each role, to try something new, to push barriers and surprise jaded viewers.
From character actor to action to schlock
Early in his career, Cage established himself as an off-beat character actor renowned for his eccentric vocal delivery, his commitment to the Method, and his ability to effortlessly pivot between genres.
In quick succession, he made Peggy Sue Got Married (1986, directed by his uncle, Francis Ford Coppola), Raising Arizona (1987), Moonstruck (1987), and Vampire?s Kiss (1988). None of these films are alike.
Co-stars were both baffled and bewildered. Some admired his verve that pushed performance to the limits. Others were dismayed at his peculiar decisions and what they saw as a ?look-at-me? descent into excess and histrionics.
By 1996, with an Oscar win for Leaving Las Vegas (1995) as an alcoholic screenwriter seeking redemption, Cage had announced himself as a star.
?
Cage shortly became a fully-fledged 90s action hero, with roles in The Rock (1996), Con Air (1997), and Face/Off (1997).
Watched back now, those performances seem to foreshadow Cage?s descent into self-parody, but at the time it was refreshing to see Cage play roles usually reserved for Bruce Willis or Arnold Schwarzenegger.
He was a nerdy everyman, with a lithe, fluid body. His nerdiness and ad-libbing was a refreshing antidote to the muscular action stars.
For sure, there were missteps along the way as he navigated his newfound status: the tabloid press had a field day reporting on his lavish spending. But in an era of changing modes of film distribution, audience fragmentation, and the existential demise of the film star, his presence felt both reassuring and addictive.
We looked forward to what he would do next.
But the wheels soon fell off. Cage drifted into generic video-on-demand schlock, such as Rage (2014) and The Runner (2015).
He has vigorously defended this work, but the suspicion remains he was motivated by commerce, not art.
At the same time, the Internet, and in particular meme and gif culture, began to work alongside Cage?s career, both undermining and reinforcing his peculiar brand of stardom.
Fan edits, memes, and YouTube mashups eventually became a source of great frustration for Cage as he struggled to reassure fans and critics alike he was a serious performer.
?
But this was not always backed up by his career choices or his own pronouncements on his craft. Sean Penn, his contemporary and early rival, disparagingly called him a ?performer.? Cage referred to himself as a thespian, a troubadour entertaining the mob.
Most intriguing, he defined his heightened acting style as ?nouveau shamanism?: a singular blend of trancelike ?being? and pure Kabuki ?playacting.?
For some, Cage?s ideas gloriously pointed to the new direction film acting was headed: brave, gonzo, idiosyncratic. For others, it cemented his status as a self-promoting charlatan.
His finest performances
So it comes as a great relief that the last five years or so have heralded a remarkable return to form for Cage.
His career was revitalised in 2018 with a quite extraordinary performance as the grieving lover turned avenging angel in Mandy. There is a scene from that film which distills Cage?s career into 60 magnificent seconds.
Sat alone in a garishly lit bathroom, he chugs a bottle of vodka, moans, and mumbles and screams with grief. The ?Cage Rage,? as it has become known, is there in full technicolour detail.
?
He followed that up with two memorably strange films: Colour Out Of Space (2019) and Willy?s Wonderland (2020).
The first is a Lovecraftian tale of meteors, glowing goo, and hostile alpacas. In the latter, he plays the silent janitor of a demonically possessed funhouse.
Cage attacks both roles with typical insouciance and stoic resignation.
But best of all is Pig (2021). Here, Cage plays a grieving chef who has retreated to the Oregon wilderness with only a truffle-hunting pig for company. When the pig is kidnapped, Cage re-enters the world, intent on finding his only true companion.
Gone is the Elvis coolness of Wild At Heart (1990), the physical dexterity of National Treasure (2004), and the childlike blankness of City of Angels (1998). In Pig, Cage is bloated and bearded, wracked by grief and remorse.
It is one of his finest performances.
The Unbearable Weight of Massive Talent once more showcases Cage?s skills. He remains an intense, immersive actor whose career blends kitsch and Method commitment and who realises that stardom ? and what it means to be a movie star ? has changed.
As he once famously said: ?You tell me where the top is, and I?ll tell you whether or not I?m over it.?
This article was originally published on The Conversation. Read the original article.

                    

                        If you’re interested in writing for International Policy Digest – please send us an email via submissions@intpolicydigest.org
                    
We  wish to  give thanks to the author of this  short article for this  outstanding content



Nicolas Cage is the Most Fascinating and Exciting Actor Working Today


                        )

                    [summary] => In Nicolas Cage?s latest film, The Unbearable Weight of Massive Talent, Cage plays a character called?Nick Cage. This meta-commentary on fame and celebrity, wrapped around a thriller plot, is full of Cage-inspired ?Easter eggs? and knowing nods to the audience. Once again, Cage reminds us that he might just be the most interesting and exciting ... Read more
                    [atom_content] => 

In Nicolas Cage?s latest film, The Unbearable Weight of Massive Talent, Cage plays a character called?Nick Cage. This meta-commentary on fame and celebrity, wrapped around a thriller plot, is full of Cage-inspired ?Easter eggs? and knowing nods to the audience.
Once again, Cage reminds us that he might just be the most interesting and exciting actor working in mainstream cinema today.
As a Cage super-fan, I?ve always been struck by his prodigious work ethic (over 100 films, many shot back-to-back or concurrently); his appeal to venerated auteurs like David Lynch, Werner Herzog, and Martin Scorsese; his eclectic, quirky choices that bamboozle us; and his approach to stardom.
?
Take three other actors of a similar age: Cage is not Tom Cruise, whose precision-engineered career allows no risks to be taken. Nor is he Jim Carrey, whose early career blazed brightly and then faded away. Nor is he George Clooney, who has traded stardom for activism and advocacy.
Cage?s take on stardom is different: a chance to reinvent himself with each role, to try something new, to push barriers and surprise jaded viewers.
From character actor to action to schlock
Early in his career, Cage established himself as an off-beat character actor renowned for his eccentric vocal delivery, his commitment to the Method, and his ability to effortlessly pivot between genres.
In quick succession, he made Peggy Sue Got Married (1986, directed by his uncle, Francis Ford Coppola), Raising Arizona (1987), Moonstruck (1987), and Vampire?s Kiss (1988). None of these films are alike.
Co-stars were both baffled and bewildered. Some admired his verve that pushed performance to the limits. Others were dismayed at his peculiar decisions and what they saw as a ?look-at-me? descent into excess and histrionics.
By 1996, with an Oscar win for Leaving Las Vegas (1995) as an alcoholic screenwriter seeking redemption, Cage had announced himself as a star.
?
Cage shortly became a fully-fledged 90s action hero, with roles in The Rock (1996), Con Air (1997), and Face/Off (1997).
Watched back now, those performances seem to foreshadow Cage?s descent into self-parody, but at the time it was refreshing to see Cage play roles usually reserved for Bruce Willis or Arnold Schwarzenegger.
He was a nerdy everyman, with a lithe, fluid body. His nerdiness and ad-libbing was a refreshing antidote to the muscular action stars.
For sure, there were missteps along the way as he navigated his newfound status: the tabloid press had a field day reporting on his lavish spending. But in an era of changing modes of film distribution, audience fragmentation, and the existential demise of the film star, his presence felt both reassuring and addictive.
We looked forward to what he would do next.
But the wheels soon fell off. Cage drifted into generic video-on-demand schlock, such as Rage (2014) and The Runner (2015).
He has vigorously defended this work, but the suspicion remains he was motivated by commerce, not art.
At the same time, the Internet, and in particular meme and gif culture, began to work alongside Cage?s career, both undermining and reinforcing his peculiar brand of stardom.
Fan edits, memes, and YouTube mashups eventually became a source of great frustration for Cage as he struggled to reassure fans and critics alike he was a serious performer.
?
But this was not always backed up by his career choices or his own pronouncements on his craft. Sean Penn, his contemporary and early rival, disparagingly called him a ?performer.? Cage referred to himself as a thespian, a troubadour entertaining the mob.
Most intriguing, he defined his heightened acting style as ?nouveau shamanism?: a singular blend of trancelike ?being? and pure Kabuki ?playacting.?
For some, Cage?s ideas gloriously pointed to the new direction film acting was headed: brave, gonzo, idiosyncratic. For others, it cemented his status as a self-promoting charlatan.
His finest performances
So it comes as a great relief that the last five years or so have heralded a remarkable return to form for Cage.
His career was revitalised in 2018 with a quite extraordinary performance as the grieving lover turned avenging angel in Mandy. There is a scene from that film which distills Cage?s career into 60 magnificent seconds.
Sat alone in a garishly lit bathroom, he chugs a bottle of vodka, moans, and mumbles and screams with grief. The ?Cage Rage,? as it has become known, is there in full technicolour detail.
?
He followed that up with two memorably strange films: Colour Out Of Space (2019) and Willy?s Wonderland (2020).
The first is a Lovecraftian tale of meteors, glowing goo, and hostile alpacas. In the latter, he plays the silent janitor of a demonically possessed funhouse.
Cage attacks both roles with typical insouciance and stoic resignation.
But best of all is Pig (2021). Here, Cage plays a grieving chef who has retreated to the Oregon wilderness with only a truffle-hunting pig for company. When the pig is kidnapped, Cage re-enters the world, intent on finding his only true companion.
Gone is the Elvis coolness of Wild At Heart (1990), the physical dexterity of National Treasure (2004), and the childlike blankness of City of Angels (1998). In Pig, Cage is bloated and bearded, wracked by grief and remorse.
It is one of his finest performances.
The Unbearable Weight of Massive Talent once more showcases Cage?s skills. He remains an intense, immersive actor whose career blends kitsch and Method commitment and who realises that stardom ? and what it means to be a movie star ? has changed.
As he once famously said: ?You tell me where the top is, and I?ll tell you whether or not I?m over it.?
This article was originally published on The Conversation. Read the original article.

                    

                        If you’re interested in writing for International Policy Digest – please send us an email via submissions@intpolicydigest.org
                    
We  wish to  give thanks to the author of this  short article for this  outstanding content



Nicolas Cage is the Most Fascinating and Exciting Actor Working Today


                    [date_timestamp] => 1651194173
                )

            [8] => Array
                (
                    [title] => Le Pagelle ai Nuovi Singoli italiani in uscita Venerdi 29 Aprile: questa settimana stupiscono le donne? Meg, Svegliaginevra e Cmqmartina
                    [link] => https://moustachebrothers.com/music/le-pagelle-ai-nuovi-singoli-italiani-in-uscita-venerdi-29-aprile-questa-settimana-stupiscono-le-donne-meg-svegliaginevra-e-cmqmartina/
                    [dc] => Array
                        (
                            [creator] => Tom Pauler
                        )

                    [pubdate] => Fri, 29 Apr 2022 00:02:53 +0000
                    [category] => MusicaprileCmqmartinadonneitalianiMegnuoviPagellequestasettimanasingolistupisconoSvegliaginevrauscitaVenerdi
                    [guid] => https://moustachebrothers.com/?p=36597
                    [description] => Pagelle nuovi singoli italiani in uscita il 29 aprile 2022 a cura di Fabio Fiume. Un nuovo Venerdi e nuove pagelle su All Music Italia. Questa settimana ho ascoltato alcuni piacevoli ritorni, qualche bella sorpresa da un passato non troppo recente e qualche cambio di rotta che merita più approfonditi ascolti di altro materiale per ... Read more
                    [content] => Array
                        (
                            [encoded] => 

Pagelle nuovi singoli italiani in uscita il 29 aprile 2022 a cura di Fabio Fiume.
Un nuovo Venerdi e nuove pagelle su All Music Italia. Questa settimana ho ascoltato alcuni piacevoli ritorni, qualche bella sorpresa da un passato non troppo recente e qualche cambio di rotta che merita più approfonditi ascolti di altro materiale per capire per bene dove si stia andando.
Cominciamo subito?
Aiello ? Paradiso
E? la descrizione dell?innamoramento, la fase più bella di una storia ed anche quella in cui ognuno di noi rivela delle paure inconsce. Come sarà, piacerò davvero, i miei odori, il mio modo di fare l?amore? E tutto ha una risposta solo vivendo, solo cercando di esplorare quel paradiso. Batte meno sulla voce come nel più recente passato, dove forse aveva un po? esagerato. Meglio, decisamente meglio. Ci voleva però una piccola evoluzione. E? tutto troppo tirato a corto.
Sei

Emanuele Aloia ? Cartagine
Pezzo che sembra avere parecchie partenze, ad ogni due battute di strofe e poi invece gioca di pazienza fino all?inciso che viene lanciato come up tempo ed invece resta inchiodato ad un formato ballata elettronica. E proprio nello stesso inciso che c?è un po? di confusione di fondo in un arrangiamento che diventa chiassoso e che di certo non viene aiutato dal coro di voci bianche in entrata. Inutile dire che non sorvolerò poi su quell? impèro al posto di impero, che è davvero uno schiaffo imperdonabile in pieno volto. E lo è all?italiano!
Quattro

Luca Barbarossa & Extraliscio ? E? così
Secondo il mio parere, da quando negli ultimi anni Luca Barbarossa s?è tolto dalla testa la spada di Damocle del dover ad ogni costo impressionare le classifiche, ha trovato una nuova ispirazione di grande valore. E? melodicamente impeccabile, si concede spazi ariosi dove cantare di sentimenti espressi con la forza della maturità e l?importanza di quanto sia potente il saperli dire, ammettere. Bella anche la partecipazione degli Extraliscio, giusti nell?intervento vocale, perfetti nella loro musicalità di sapiente miscela fra il pop e il folk tradizionale. Notevole.
Otto

Drko ? Upsidedown
Semplicistica ma tutto sommato realizzata con un certo criterio. E? evidente la giovane età ed anche il filone modaiolo che viene seguito a livello d?arrangiamento. Resta però espressa in maniera cantilenata, in un inciso che ricorda quelle filastrocche che s?imparano da bambini e che, basta un nulla, ti tornano in mente all?improvviso e le ricordi tutte per intero. Glielo lascio come augurio.
Sei 

Elasi ? Sottopelle
Potrebbe dare una sensazione trasognata a primo acchito ed invece? Elasi parla di sogni etilici. Non è chiarissimo il testo, complici alcune ?e? talmente strette , che sembrano delle ?i?. Il mondo è quello di un?elettronica parecchio enfatizzata, alla Bath For Lashes dei tempi migliori, ma manca quel gancio, quella particolarità che svegli dalla prevedibilità del percorso e dalle sue ripetizioni.
Cinque + 

Eman ? Il matto
Nuova modalità cantautorale energica, intelligente e sufficientemente ironica, tanto da riuscire a dire cose invece serie- Il Matto è dentro tutti noi. in tutti quelli che non riconoscono che se si va troppo forte si corre il rischio di vivere a metà il presente. Bello anche l?arrangiamento da menestrello moderno.
Sette+

Garibaldi ? Non mi va
Un po? dance, un po? da banda vagante per il paese, questo singolo poi spariglia tutto con un fare da ballata un filo incazzata nelle strofe, alla Fabrizio Moro per assonanze. L?idea potrebbe anche essere considerata originale, anzi senz?altro lo è, ma l?inciso che è solo la ripetizione di una frase ad oltranza impoverisce un po? il tutto. Il finale è quasi da avanspettacolo, un po? ardito per le radio.
Cinque=
Clicca in basso su continua per la seconda parte pagelle nuovi singoli del 29 aprile.

We  would love to  say thanks to the author of this article for this awesome  web content



Le Pagelle ai Nuovi Singoli italiani in uscita Venerdi 29 Aprile: questa settimana stupiscono le donne… Meg, Svegliaginevra e Cmqmartina


                        )

                    [summary] => Pagelle nuovi singoli italiani in uscita il 29 aprile 2022 a cura di Fabio Fiume. Un nuovo Venerdi e nuove pagelle su All Music Italia. Questa settimana ho ascoltato alcuni piacevoli ritorni, qualche bella sorpresa da un passato non troppo recente e qualche cambio di rotta che merita più approfonditi ascolti di altro materiale per ... Read more
                    [atom_content] => 

Pagelle nuovi singoli italiani in uscita il 29 aprile 2022 a cura di Fabio Fiume.
Un nuovo Venerdi e nuove pagelle su All Music Italia. Questa settimana ho ascoltato alcuni piacevoli ritorni, qualche bella sorpresa da un passato non troppo recente e qualche cambio di rotta che merita più approfonditi ascolti di altro materiale per capire per bene dove si stia andando.
Cominciamo subito?
Aiello ? Paradiso
E? la descrizione dell?innamoramento, la fase più bella di una storia ed anche quella in cui ognuno di noi rivela delle paure inconsce. Come sarà, piacerò davvero, i miei odori, il mio modo di fare l?amore? E tutto ha una risposta solo vivendo, solo cercando di esplorare quel paradiso. Batte meno sulla voce come nel più recente passato, dove forse aveva un po? esagerato. Meglio, decisamente meglio. Ci voleva però una piccola evoluzione. E? tutto troppo tirato a corto.
Sei

Emanuele Aloia ? Cartagine
Pezzo che sembra avere parecchie partenze, ad ogni due battute di strofe e poi invece gioca di pazienza fino all?inciso che viene lanciato come up tempo ed invece resta inchiodato ad un formato ballata elettronica. E proprio nello stesso inciso che c?è un po? di confusione di fondo in un arrangiamento che diventa chiassoso e che di certo non viene aiutato dal coro di voci bianche in entrata. Inutile dire che non sorvolerò poi su quell? impèro al posto di impero, che è davvero uno schiaffo imperdonabile in pieno volto. E lo è all?italiano!
Quattro

Luca Barbarossa & Extraliscio ? E? così
Secondo il mio parere, da quando negli ultimi anni Luca Barbarossa s?è tolto dalla testa la spada di Damocle del dover ad ogni costo impressionare le classifiche, ha trovato una nuova ispirazione di grande valore. E? melodicamente impeccabile, si concede spazi ariosi dove cantare di sentimenti espressi con la forza della maturità e l?importanza di quanto sia potente il saperli dire, ammettere. Bella anche la partecipazione degli Extraliscio, giusti nell?intervento vocale, perfetti nella loro musicalità di sapiente miscela fra il pop e il folk tradizionale. Notevole.
Otto

Drko ? Upsidedown
Semplicistica ma tutto sommato realizzata con un certo criterio. E? evidente la giovane età ed anche il filone modaiolo che viene seguito a livello d?arrangiamento. Resta però espressa in maniera cantilenata, in un inciso che ricorda quelle filastrocche che s?imparano da bambini e che, basta un nulla, ti tornano in mente all?improvviso e le ricordi tutte per intero. Glielo lascio come augurio.
Sei 

Elasi ? Sottopelle
Potrebbe dare una sensazione trasognata a primo acchito ed invece? Elasi parla di sogni etilici. Non è chiarissimo il testo, complici alcune ?e? talmente strette , che sembrano delle ?i?. Il mondo è quello di un?elettronica parecchio enfatizzata, alla Bath For Lashes dei tempi migliori, ma manca quel gancio, quella particolarità che svegli dalla prevedibilità del percorso e dalle sue ripetizioni.
Cinque + 

Eman ? Il matto
Nuova modalità cantautorale energica, intelligente e sufficientemente ironica, tanto da riuscire a dire cose invece serie- Il Matto è dentro tutti noi. in tutti quelli che non riconoscono che se si va troppo forte si corre il rischio di vivere a metà il presente. Bello anche l?arrangiamento da menestrello moderno.
Sette+

Garibaldi ? Non mi va
Un po? dance, un po? da banda vagante per il paese, questo singolo poi spariglia tutto con un fare da ballata un filo incazzata nelle strofe, alla Fabrizio Moro per assonanze. L?idea potrebbe anche essere considerata originale, anzi senz?altro lo è, ma l?inciso che è solo la ripetizione di una frase ad oltranza impoverisce un po? il tutto. Il finale è quasi da avanspettacolo, un po? ardito per le radio.
Cinque=
Clicca in basso su continua per la seconda parte pagelle nuovi singoli del 29 aprile.

We  would love to  say thanks to the author of this article for this awesome  web content



Le Pagelle ai Nuovi Singoli italiani in uscita Venerdi 29 Aprile: questa settimana stupiscono le donne… Meg, Svegliaginevra e Cmqmartina


                    [date_timestamp] => 1651190573
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                    [title] => Unravelling the origins of the human spine
                    [link] => https://moustachebrothers.com/healthandscience/unravelling-the-origins-of-the-human-spine/
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                        (
                            [creator] => Tony Grantly
                        )

                    [pubdate] => Thu, 28 Apr 2022 23:52:00 +0000
                    [category] => Health And SciencehumanOriginsspineUnravelling
                    [guid] => https://moustachebrothers.com/?p=36590
                    [description] => Journal Reference: Marina Sanaki-Matsumiya, Mitsuhiro Matsuda, Nicola Gritti, Fumio Nakaki, James Sharpe, Vikas Trivedi, Miki Ebisuya. Periodic formation of epithelial somites from human pluripotent stem cells. Nature Communications, 2022; 13 (1) DOI: 10.1038/s41467-022-29967-1 The spinal column consists of 33 vertebrae, which form pairs of precursor structures called somites. Somites give rise to not only our ... Read more
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Journal Reference:

Marina Sanaki-Matsumiya, Mitsuhiro Matsuda, Nicola Gritti, Fumio Nakaki, James Sharpe, Vikas Trivedi, Miki Ebisuya. Periodic formation of epithelial somites from human pluripotent stem cells. Nature Communications, 2022; 13 (1) DOI: 10.1038/s41467-022-29967-1


The spinal column consists of 33 vertebrae, which form pairs of precursor structures called somites. Somites give rise to not only our vertebrae, but also our ribs and skeletal muscles. To ensure that these structures are formed correctly, somite development is tightly regulated, and each pair of somites arises at a particular sequential time point in development. This process is controlled by the segmentation clock, which is a group of genes that creates oscillatory waves, every wave giving rise to a new pair of somites.
?For the first time, we have been able to create periodic pairs of human mature somites linked to the segmentation clock in the lab,? said Marina Sanaki-Matsumiya, first author of the study published in Nature Communications. Using this approach, the researchers developed a 3D in vitro model of human somite formation, also known as ?somitogenesis?.
Creating a robust somitogenesis process
The team cultured human induced pluripotent stem cells (hiPSC) in the presence of a cocktail of signalling molecules that induce cell differentiation. Three days later, the cells started to elongate and create anterior (top) and posterior (bottom) axes. At that point, the scientists added Matrigel to the culture mix. Matrigel is what some scientists call the magic powder: a protein mixture that is critical to many developmental processes. This process eventually led to the formation of somitoids ? in vitro equivalents of human somite precursor structures.
To test whether the segmentation clock regulates somitogenesis in these somitoids, the researchers monitored the expression patterns of HES7, the core gene involved in the process. They found clear evidence of oscillations, especially when somitogenesis was about to start. The somites that formed also had clear markers of epithelization ? an important step in their maturation.
Somite size matters
The Ebisuya group studies how and why we humans are different from other species when it comes to embryonic development. One of the model systems they use to understand interspecies differences is the segmentation clock. In 2020, the group uncovered that the oscillation period of the human segmentation clock is longer than the mouse segmentation clock.
The current study also shows a link between the size of somites and the segmentation clock. ?The somites that were generated had a constant size, independently of the number of cells used for the initial somitoid. The somite size did not increase even if the initial cell number did.? explained Sanaki-Matsumiya. ?This suggests that the somites have a preferred species-specific size, which might be determined by local cell-cell interactions, the segmentation clock, or other mechanisms.?
To study this further, Miki Ebisuya and her group are now planning to grow somitoids of different species and compare them. The researchers are already working on several mammalian species, including rabbits, cattle, and rhinoceroses, setting up a ?stem cell zoo? in the lab.
?Our next project will focus on creating somitoids from different species, measure their cell proliferation and cell migration speed to establish what and how somitogenesis is different among species,? said Ebisuya.

We  would love to  say thanks to the author of this article for this  outstanding  material



Unravelling the origins of the human spine


                        )

                    [summary] => Journal Reference: Marina Sanaki-Matsumiya, Mitsuhiro Matsuda, Nicola Gritti, Fumio Nakaki, James Sharpe, Vikas Trivedi, Miki Ebisuya. Periodic formation of epithelial somites from human pluripotent stem cells. Nature Communications, 2022; 13 (1) DOI: 10.1038/s41467-022-29967-1 The spinal column consists of 33 vertebrae, which form pairs of precursor structures called somites. Somites give rise to not only our ... Read more
                    [atom_content] => 

Journal Reference:

Marina Sanaki-Matsumiya, Mitsuhiro Matsuda, Nicola Gritti, Fumio Nakaki, James Sharpe, Vikas Trivedi, Miki Ebisuya. Periodic formation of epithelial somites from human pluripotent stem cells. Nature Communications, 2022; 13 (1) DOI: 10.1038/s41467-022-29967-1


The spinal column consists of 33 vertebrae, which form pairs of precursor structures called somites. Somites give rise to not only our vertebrae, but also our ribs and skeletal muscles. To ensure that these structures are formed correctly, somite development is tightly regulated, and each pair of somites arises at a particular sequential time point in development. This process is controlled by the segmentation clock, which is a group of genes that creates oscillatory waves, every wave giving rise to a new pair of somites.
?For the first time, we have been able to create periodic pairs of human mature somites linked to the segmentation clock in the lab,? said Marina Sanaki-Matsumiya, first author of the study published in Nature Communications. Using this approach, the researchers developed a 3D in vitro model of human somite formation, also known as ?somitogenesis?.
Creating a robust somitogenesis process
The team cultured human induced pluripotent stem cells (hiPSC) in the presence of a cocktail of signalling molecules that induce cell differentiation. Three days later, the cells started to elongate and create anterior (top) and posterior (bottom) axes. At that point, the scientists added Matrigel to the culture mix. Matrigel is what some scientists call the magic powder: a protein mixture that is critical to many developmental processes. This process eventually led to the formation of somitoids ? in vitro equivalents of human somite precursor structures.
To test whether the segmentation clock regulates somitogenesis in these somitoids, the researchers monitored the expression patterns of HES7, the core gene involved in the process. They found clear evidence of oscillations, especially when somitogenesis was about to start. The somites that formed also had clear markers of epithelization ? an important step in their maturation.
Somite size matters
The Ebisuya group studies how and why we humans are different from other species when it comes to embryonic development. One of the model systems they use to understand interspecies differences is the segmentation clock. In 2020, the group uncovered that the oscillation period of the human segmentation clock is longer than the mouse segmentation clock.
The current study also shows a link between the size of somites and the segmentation clock. ?The somites that were generated had a constant size, independently of the number of cells used for the initial somitoid. The somite size did not increase even if the initial cell number did.? explained Sanaki-Matsumiya. ?This suggests that the somites have a preferred species-specific size, which might be determined by local cell-cell interactions, the segmentation clock, or other mechanisms.?
To study this further, Miki Ebisuya and her group are now planning to grow somitoids of different species and compare them. The researchers are already working on several mammalian species, including rabbits, cattle, and rhinoceroses, setting up a ?stem cell zoo? in the lab.
?Our next project will focus on creating somitoids from different species, measure their cell proliferation and cell migration speed to establish what and how somitogenesis is different among species,? said Ebisuya.

We  would love to  say thanks to the author of this article for this  outstanding  material



Unravelling the origins of the human spine


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